WebIDP-73152, a novel peptide deformylase inhibitor with an antibacterial effect against Gram-positive bacteria, is in phase I development. The objective of this study was to develop a physiologically-based pharmacokinetic model (PBPK) for IDP-73152 in animals, and to extend the model to humans. Biopharmaceutical properties of IDP-73152 are determined … WebIn the present study, we describe the characteristics of McH/lpr-RA1 mice and propose their use as a novel murine model of autoimmune sialadenitis. The McH/lpr-RA1 mouse is a recombinant congenic strain derived from generation F54 or more of MRL-Fas lpr x (MRL- Fas lpr x C3H- Fas lpr) F1. We show for the first time that this mouse spontaneously ...
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WebFeb 6, 2013 · The present study has developed a novel model of lymph-node metastasis, based on the injection of KM-Luc/GFP cells into the SiLNs of MRL/lpr mice exhibiting remarkable systemic lymphadenopathy. The importance of this new model is that it is ideally suited for use in the development of imaging modalities to improve the assessment of … Web1 day ago · To this end, we employed a novel HCO 3--selective europium probe and incorporated this probe within ... at 3.3 Å was of high quality and allowed the unambiguous interpretation of the cryo-EM density by an atomic model ... purified SLC26A6 was added at an lipid-to-protein ratio (LPR) of 50:1. To counteract [Eu.L1 +] probe leakage, an ... gibbs smith covers
IJMS Free Full-Text A New Target of Dental Pulp-Derived Stem …
WebJan 27, 2024 · LPR disease (LPRD) is considered to be the extraesophageal manifestation of gastroesophageal reflux disease (GERD) . As it is difficult to study the pathophysiology … WebProperties of a Novel Animal Model of LPR. @article{Cao2024PropertiesOA, title={Properties of a Novel Animal Model of LPR.}, author={Jie Cao and Lihong Zhang … WebInterleukin-8 (IL-8) and vascular endothelial growth factor (VEGF) may be associated with the pathogenesis of LPR injuries and laryngeal carcinomas. Objectives To establish an … frp blackberry priv