WebJul 21, 2008 · A range of monocationic and dicationic dioxyalkylglycerol cytofectins have been synthesised possessing methylene and short n-ethylene glycol spacers. The monocationic compounds were found to be effective in transfections when formulated as lipopolyplexes with peptide and DNA components, in particular with shorter PEG head … WebFeb 5, 1999 · The most promising advances in nonviral gene transfer have been in the production of synthetic cationic liposomes formulated with cationic lipids (cytofectins) able to transfect cells. Such...
CA2251169A1 - Quaternary cytofectins - Google Patents
WebTypically, cytofectins are combined with a neutral zwitterionic lipid such as a phospholipid, because it has been found that the two amphiphilic lipid species in combination are able … Webcytofectins transfective derivatized Prior art date 1996-04-09 Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) Granted Application number CA002251169A Other languages French (fr) Other versions ... how many people fly
Effect of cytofectins on the immune response of murine
WebDec 21, 2001 · We report herein the design, synthesis, and transfection biology of a novel series of non-glycerol-based cationic lipids with lactic acid-derived head groups The synthetic procedure adopted herein for preparing 1-hydroxy-prop-2-yl head-group-based monocationic transfection lipids 1–7 is fairly straightforward and potentially applicable in … WebBoth single-stranded and double-stranded DNAs were active in the presence of cytofectins. Macrophage activation by the DNA-cytofectin complexes was reduced by chloroquine, … WebA large number of liposome-based non-viral gene and siRNA delivery systems include monovalent cholesteryl cytofectins with acyclic head groups in their formulations. … how many people fly a year