Cisplatin hepatotoxicity
WebJan 14, 2024 · This study was designed to investigate the protective effects of Centella asiatica (CA) on cisplatin-induced hepatotoxicity and to clarify the underlying … WebSynergism of cisplatin-oleanolic acid co-loaded calcium carbonate nanoparticles on hepatocellular carcinoma cells for enhanced apoptosis and reduced hepatotoxicity. …
Cisplatin hepatotoxicity
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WebFeb 1, 2024 · Hesperidin plays an important role in the prevention of many diseases due to its anti-inflammatory, anti-oxidant, anti-ulcer, and anti-carcinogenic activities,2,3in addition to its anti-melanogenic and neuroprotective effects.4,5Moreover, it has anti-microbial, anti-allergic, immunomodulatory, hepatoprotective, and nephroprotective effects.6-8The … WebDec 1, 2024 · 1.2. Toxicity of cisplatin. Cisplatin can be considered a double-edged sword. It is a potent anticancer agent, at the same time has toxic effect on various tissues as it …
WebThe results suggest that the plant extract (250 and 500 mg/kg) was effective in significantly altering the indices of cisplatin induced dysfunction of renal proximal tubule cells under oxidative stress by decreasing the concentration of … WebCisplatin (cis-diamminedichloroplatinium, CDDP), one of the most widely used chemotherapeutic drugs for a variety of tumors, exhibits anticancer activity via formation of CDDP-DNA adducts. 6 However, its clinical use has been hampered by the intrinsic and adaptive resistances of the tumor cells along with severe toxic effects, which greatly …
WebDrug-induced liver injury (DILI) is the most common cause of acute liver failure worldwide. 1, 2 Cisplatin (CP) is one of the most common and potent anti-neoplastic agents used against testicular, ovarian, cervical, as well as bladder malignancies. 3 – 6 Despite its effectiveness, CP use is limited due to its serious toxic side effects such as … WebMar 13, 2024 · Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the severe …
WebOne of greatest key mechanisms of Cis toxicity is the induction of oxidative stress. Under normal conditions, ROS are controlled by cells through harmonizing the production of ROS with their removal by scavenging system. Oxidative stress results in extreme damage of cellular proteins, lipids and DNA, leading to critical cellular injuries.
WebCisplatin is a platinum-based chemotherapeutic that has long since been effective against a variety of solid-cancers, substantially improving the five-year survival rates for cancer patients. Its use has also historically been limited by its adverse drug reactions, or cisplatin-induced toxicities (CITs). phobia of pukingWebabstract = "Generation of free radicals in the kidney cortex plays an important role in the pathogenesis of cisplatin-induced dysfunction of renal proximal tubule cells. tswintech.co.krWebCisplatin is a platinum containing drug first approved as an antineoplastic agent in 1978. It remains an important and effective therapy in many forms of cancer today. Cisplatin mediates its tumorcidal effects via a number of different cytotoxic mechanisms. Although it is best known for DNA damage, … phobia of reptilesWebJul 22, 2024 · Cisplatin-induced kidney toxicity is reviewed here. The use of cisplatin in patients with pre-existing kidney dysfunction and the kidney effects of the platinum … phobia of rabbitsWebTo date, no published guidelines exist for managing a cisplatin overdose. The major toxicities of a cisplatin overdose include nausea and vomiting, renal insufficiency, … phobia of redheadsWebPreventive Effect of Curcumin against Cisplatin-related Hepatotoxicity in Swiss Albino mice (Mus musculus L.) Jul 2024 - Jun 2024 … phobia of ravensWebCisplatin is one of the most potent cytotoxic anticancer medicines; nonetheless, hepatotoxicity and lymphotoxicity are two of its significant adverse effects, which … tsw international flights