Chromopyrrolic acid

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August undefined, 2024

WebDec 29, 2004 · The following compounds were purified from S. albus harboring the plasmids mentioned in brackets: chromopyrrolic acid 1 (pCS014), K-252c or staurosporine aglycone 3 (pCS039), 11-chlorochromopyrrolic acid 7 (pCS018), 1-chloroarcyriaflavin 9 (pCS020), 9-chlorochromopyrrolic acid 21 (pCS049) and 3-chloroarcyriaflavin 23 (pCS037). WebIndole-3-pyruvic acid can be used: As a precursor for the synthesis of chromopyrrolic acid by a heme-containing enzyme.As a reactant in the Biginelli-like scaffold syntheses. Packaging. 1, 5 g in poly bottle. Linkage. α-Keto analogue …

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WebSep 25, 2007 · The minor peaks indicate that, at low levels, chromopyrrolic acid spontaneously degrades under aerobic conditions at room temperature. This result … WebJan 23, 2006 · Chromopyrrolic acid is indicated by filled arrow head, and indole-3-pyruvic acid is indicated by blank arrow heads. Presumably, because of the coexistence of keto … polytec light oak ravine

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WebCHEBI:41625 - chromopyrrolic acid. A pyrroledicarboxylic acid that is pyrrole-2,5-dicarboxylic acid in which the hydrogens at positions 3 and 4 have been replaced … WebJan 11, 2005 · The results suggest that indolocarbazole is constructed by oxidative decarboxylation of chromopyrrolic acid generated from two molecules of tryptophan by coupling and that the oxidation state at the C-7 position depends on the additional enzyme(s) encoded by the biosynthetic genes. Expand polytech wittelsheim

Staurosporine and Rebeccamycin Aglycones Are Assembled by the …

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WebJan 1, 2006 · Chromopyrrolic acid is oxidized by six electrons compared to the starting pair of L-tryptophan molecules. RebO is an L-tryptophan oxidase flavoprotein and RebD … WebSep 25, 2007 · The biosynthesis of rebeccamycin, an antitumor compound, involves the remarkable eight-electron oxidation of chlorinated chromopyrrolic acid. Although one rebeccamycin biosynthetic enzyme is capable of generating low levels of the eight-electron oxidation product on its own, a second protein, RebC, is required to accelerate product … polytech windows and doors reviewsWebApr 16, 2007 · Indole-3-pyruvic acid is transformed to prodeoxyviolacein by the novel enzyme VioE, which is involved in the violacein biosynthetic pathway in Chromobacterium violaceum ATCC12472. VioE catalyzes the decarboxylation and indole-ring rearrangement of a nascent compound that is produced from indole-3-pyruvic acid and NH 4 + by the … shannon fallon

"Webchlorination of chromopyrrolic acid or arcyriaflavin was detected when we fed either of these compounds to a S. albus strain expressing rebH. In contrast, coexpression of rebODH or rebOD-CPH yielded chloro and dichloro versions of chromopyrrolic acid (compounds 7 and 10), A S. albus andA ... " - Chromopyrrolic acid

Chromopyrrolic acid

Indole-3-pyruvic acid = 97 392-12-1 - Sigma-Aldrich

WebApr 24, 2009 · Chromopyrrolic acid 11 is a shunt product and not a precursor to violacein (Balibar and Walsh, 2006, Sánchez et al., 2006a). A filtration-HPLC assay established that VioE, the next enzyme in the pathway, acts on an as yet uncharacterized intermediate produced by VioB to generate prodeoxyviolacein 19 (Balibar and Walsh, 2006). Web暨南大学,数字图书馆. 开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆

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Webtion of tryptophan to the imine form of indole-3-pyruvic acid (IPA imine), and StaD then catalyzes the coupling of two molecules of IPA imine to yield chromopyrrolic acid (CPA). Finally, the key skeleton structure referred to as the indolocar-bazole core is constructed through the following two oxidation steps by StaP and StaC (2, 4) (Fig. 1B). WebJan 1, 2014 · Although most P450s catalyze monooxygenation reactions, there are some exceptions. One example is P450 StaP, which is a key enzyme for forming the core structure of an anticancer agent, indolocarbazole, which catalyzes the intramolecular C–C bond formation in chromopyrrolic acid (CPA).

Web3- (3-Indolyl)-2-oxopropanoic acid, 3-Indolylpyruvic acid. Empirical Formula (Hill Notation): C11H9NO3. CAS Number: 392-12-1. Molecular Weight: 203.19. Beilstein: 172966. WebMay 20, 2024 · 多环特特拉姆酸大环内酰胺(polycyclic tetramate macrolactams，PTMs)是一类母核结构经PKS-NRPS杂合途径生物合成由特特拉姆酸(tetramic acid)结构和多环体系(常为2～3环)构成的内酰胺类化合物，具备抗肿瘤、抗细菌、抗真菌等生物活性[74].Hou等[75]前期通过培养条件优化的策略 ...

WebJun 12, 2014 · This compound was named chromopyrrolic acid, and was also detected in the various metabolites produced by the parent strain, although the amount produced … Webchromopyrrolic acid for indolocarbazole biosynthesis, whereas VioE transforms compound X into protodeoxyviolaceinic acid, which is further modified by other enzymes to produce viola-cein. Thus, VioE plays a key role in the construction of the molecular skeleton of violacein. Here, we present the crystal

WebJun 29, 2024 · 从链霉菌分离出的咔唑生物碱星孢菌素 (Staurosporine)具有强抗癌作用, 其生物合成的关键步骤是由 P450 StaP 催化底物色素吡咯酸(chromopyrrolic acid, CPA)氧化脱氢, 形成分子内 C—C 键成咔唑环, 经氧化脱羧完成.

WebApr 1, 2009 · The ‘open’ chromopyrrolic acid intermediate must be now converted into a ‘closed’ indolocarbazole aglycone either containing an imide (rebeccamycin-like as in arcyriaflavin A) or an amide (staurosporine-like as in K252c) function at the pyrrole moiety. polytec natural oak ravine sheet sizeWebChromotropic acid is a chemical compound with the formula (HO) 2 C 10 H 4 (SO 3 H) 2. It can be used for as a reagent in the quantitative determination of the herbicide 2,4 … polyteck buildingWebMay 1, 2015 · We provide the first experimental evidence for intermediates being involved in catalysis by RebD in generating the chromopyrrolic acid (CPA) scaffold of … polytec light oakWebFeb 6, 2013 · Howard-Jones, A.R.; Walsh, C.T. Enzymatic generation of the chromopyrrolic acid scaffold of rebeccamycin by the tandem action of RebO and RebD. Biochemistry 2005, 44, 15652–15663. [Google Scholar] Onaka, H. Biosynthesis of indolocarbazole and goadsporin, two different heterocyclic antibiotics produced by … polytec manchester door profileWebJul 3, 2014 · An effective and concise approach to synthesis of tetrasubstituted pyrroles from readily available amino acid esters by the promotion of Cu (OAc)2 in conjunction with Mn (OAc)3 has been developed. This reaction proceeds through multiple dehydrogenations, deamination, and oxidative cyclization. polytec light sourceWebStaP on its own converts chromopyrrolic acid into three aglycone products, K252c, arcyriaflavin A, and 7-hydroxy-K252c; in the presence of StaC, K252c is the predominant product, while the presence of RebC directs formation of arcyriaflavin A. 18 O-Labeling studies indicate that the oxygen(s) of the pyrrolinone and maleimide functionalities of ... polytec loginaccountWebChromopyrrolic Acid. Chromopyrrolic acid (55) formation is catalyzed by the chromopyrrolic acid synthase ClaD. From: The Alkaloids: Chemistry and Biology, … polytec melamine woodmatt c3